Immunostaining of Plasma Cells in Primary Biliary Cirrhosis

Immunostaining of plasma cells in primary biliary cirrhosis.

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by inflammatory destruction of the intrahepatic bile ducts. The differential diagnosis for PBC often includes autoimmune hepatitis (AIH). Both diseases can show prominent plasma cells and other overlapping histologic features. It is interesting that both diseases can involve elevated levels of serum immunoglobu...

Plasma exchange in primary biliary cirrhosis.

Introduction Primary biliary cirrhosis (chronic, destructive, nonsuppurative cholangitis) is often accompanied by unpleasant complications such as pruritus, cutaneous lipid deposits, painful 'neuropathy', occlusive vascular disease and 'cholesterol arthritis' (Mills et al., 1978; Child, Mathews and Thompson, 1977), and all may be intractable to treatment. The pathogenesis of these clinical feat...

Plasma methionine enkephalin concentration and prognosis in primary biliary cirrhosis.

Asymptomatic primary biliary cirrhosis.

Primary biliary cirrhosis.

Primary biliary cirrhosis is a chronic liver disease characterised by intrahepatic bile-duct destruction, cholestasis, and, in some cases, cirrhosis. Evidence supporting the autoimmune nature of this disorder includes the appearance of highly specific antimitochondrial antibodies (AMAs) and autoreactive T cells. Concordance rates in monozygotic twins, familial prevalence, and genetic associatio...